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马远方

博士、博导、二级教授
马远方

  博士、博导、二级教授; 抗体药物开发技术国家地方联合工程实验室主任;中国免疫学会理事、中国免疫学会基础免疫学专业委员会委员、河南省抗癌协会副理事长、河南省微生物学与免疫学学会副主任委员;国家自然科学奖、国家863计划、国家自然科学基金评审专家;河南省优秀专家、政府特殊津贴专家。主持完成国家自然科学基金3项、国家863重大专项子课题2项、国家重大新药创制子项目1项、河南省杰出人才创新基金2项等;以第一完成人获河南省科技进步二等奖2项、三等奖2项等;获国家发明专利3项。主编专著6部/副主编2部;发表学术论文200余篇,其中SCI 收录60余篇。目前主持在研国家自然科学基金1项。

主要研究方向:抗体药物研发

承担的研究项目:

1.sDR5-Fc抗体融合蛋白对猪缺血-再灌注心肌的保护作用及机制。81670271,国家自然科学基金,2017.01.01-2020.12.31,57万,主持人。

1.河南省肿瘤免疫工程创新型科技团队,30万,2015.01-2017.12,负责人。

2.热休克转录因子4b(Hsf4b)对晶状体上皮细胞增生和分化的调控机制,81270985,国家自然科学基金,2013.01-2016.12, 70万,主持人。

3.抗体研发关键技术及产品研发,2012AA02A302,国家863计划分课题,2012.01-2015.12,22万,主持人。

4.人源抗体亲和力成熟、噬菌体抗体库、抗体效应功能提高,2011ZX09506-004,国家重大新药创制科技重大专项子课题,2011.01-2013.12,40万,主持人。

5.免疫工程创新团队,2012-2015,260万。负责人。

6.OCILRP2在T细胞活化中的协同刺激作用及其机制,30972687,国家自然基金,2010.01-2012.12,33万,主持人。

7.抗死亡受体5基因工程抗体研制及其抗肿瘤作用,WKJ2007-021,卫生部科研项目,2007.1-2009.12,15万,主持人。

8.人源化及全人抗体构建及优化技术,2006AA02A254,国家863重大专项子课题,2006.12-2010.12,50万,主持人。

9.抗肿瘤DR5单抗的人源化改造,074200510014,河南省杰出人才创新基金,2007.1-2009.12,50万,主持人。

10.诱导细胞凋亡的抗DR5单抗与DR5相互作用位点分析,30571697,国家自然基金,2006.1-2008.12,26万,主持人。

11.死亡受体5单抗在恶性肿瘤诊断治疗中的应用研究,0321001800,河南省杰出人才创新基金,2004.1-2006.12,20万,主持人。

已发表论文:

(*corresponding author)

1.Wang W, Shi Q, Dou S, Li G, Shi X, Jiang X, Wang Z, Yu D, Chen G, Wang R, Xiao H, Hou C, Feng J, Shen B, Ma Y, Han G.Negative regulation of Nod-like receptor protein 3 inflammasome activation by T cell Ig mucin-3 protects against peritonitis.Immunology. 2018 ;153(1):71-83.

2.Liu RM,Sun DN,Jiao YL,Wang P,Zhang J,Wang M,Ma J,Sun M,Gu BL,Chen P,Liu K,Ma H,GaoSG,Ma YF,Qi YJ.Macrophage migration inhibitory factor promotes tumor aggressiveness of esophageal squamous cell carcinoma via activation of Akt and inactivation of GSK3β.Cancer Lett.2018 Jan 1;412:289-296.

3.Ma N, Zhang Y, Liu Q, Wang Z, Liu X, Zhu G, Yu D, Han G, Chen G, Hou C, Wang T,Ma Y,Shen B, Li Y, Xiao H, Wang R.B cell activating factor (BAFF) selects IL-10-B cells over IL-10+B cells during inflammatory responses.Mol Immunol. 2017 May;85:18-26.

4.Li X,Zhang Q, Shi Q, Liu Y, Zhao K, Shen Q, Shi Y, Liu X, Wang C, Li N,Ma Y, Cao X.Demethylase Kdm6a epigenetically promotes IL-6 and IFN-β production in macrophages.J Autoimmun. 2017 Jun;80:85-94.

5.Chen H, Zhang W, Cheng X, Guo L, Xie S, Ma Y, Guo N, Shi M.β2-AR activation induces chemoresistance by modulating p53 acetylation through upregulating Sirt1 in cervical cancer cells.Cancer Sci. 2017 May 12. doi: 10.1111/cas.13275. [Epub ahead of print]

6.Y Li, T Zhou, Y Wang, C Ning, Z Lv, G Han, JC Morris, EN Taylor, R Wang, H Xiao,C Hou,Y Ma,B Shen, J Feng, R Guo, Y Liand G Chen.The protumorigenic potential of FTY720 by promotingextramedullary hematopoiesis and MDSC accumulation.Oncogene (2017), 1–12

7.Yinan Jiang, Xiaoyan Chen, Mengya Fan, Hui Li, Weina Zhu, Xi Chen,Chenghua Cao, Rui Xu, Yaohui Wang,Yuanfang Ma*.TRAIL facilitates cytokine expression and macrophage migrationduring hypoxia/reoxygenation via ER stress-dependent NF- Bpathway.Molecular Immunology.2017;82:123-136.

8.SILEI ZHOU, HUANLING CAO, YAWEI ZHAO, XINYING LI, JIYAN ZHANG, CHUNMEI HOU, YUANFANG MA*and QINGYANG WANG.RACK1 promotes hepatocellular carcinoma cell survival via CBR1 by suppressing TNF-α-induced ROS generation.ONCOLOGY LETTERS 2016;12: 5303-5308.

9.Wang Y, Jiang Y, Zhou J, Song W, Li J, Wang M, Chen J, Xu R, Zhang J, Ma F, Chen YH, Ma Y*.Hepatitis C virus promotes hepatocellular carcinogenesis by targeting TIPE2, a new regulator of DNA damage response.Tumour Biol. 2016 Sep 30.

10.Jiang X, Zhou T, Xiao Y, Yu J, Dou S, Chen G, Wang R, Xiao H, Hou C, Wang W, Shi Q, Feng J, Ma Y, Shen B, Li Y, Han G.Tim-3 promotes tumor-promoting M2 macrophage polarization by binding to STAT1 and suppressing the STAT1-miR-155 signaling axis.Oncoimmunology. 2016 Aug 3;5(9):e1211219

11.Zhou S,Han Q,Wang R,Li X,Wang Q,Wang H,Wang J,Ma Y*. PRDX2 protects hepatocellular carcinoma SMMC-7721 cells from oxidative stress.Oncol Lett. 2016 Sep;12(3):2217-2221.

12.Cui X,Liu H,Li J,Guo K,Han W,Dong Y,Wan S,Wang X,Jia P,Li S,Ma Y,Zhang J,Mu H,Hu Y. Int J Biochem Cell Biol. 2016 Aug 30;79:118-127. Heat shock factor 4 regulates lens epithelial cell homeostasis by working with lysosome and anti-apoptosis pathways.

13.Xu X,Wang H,Liu S,Xing C,Liu Y,Aodengqimuge,Zhou W,Yuan X,Ma Y,Hu M,Hu Y,Zou S,Gu Y,Peng S,Yuan S,Li W,Ma Y,Song L. TP53-dependent autophagy links the ATR-CHEK1 axis activation to proinflammatory VEGFA production in human bronchial epithelial cells exposed to fine particulate matter (PM2.5). Autophagy. 2016 Jul 27:1-17.

14.Deng Q, Chen H, Liu Y, Xiao F, Guo L, Liu D, Cheng X, Zhao M, Wang X, Xie S, Qi S, Yin Z, Gao J, Chen X, Wang J, Guo N, Ma Y*, Shi M.Psychological stress promotes neutrophil infiltration in colon tissue through adrenergic signaling in DSS-induced colitis model.Brain Behav Immun. 2016 Apr 28. pii: S0889-1591(16)30108-8.

15.Lou Q,Hu Y,Ma Y,Dong Z.Heat shock factor 1 induces crystallin-αB to protect against cisplatin nephrotoxicity. Am J Physiol Renal Physiol. 2016 Jul 1;311(1):F94-F102.

16.Lou Q, Ma Y, Qu D.Two-component signal transduction system SaeRS is involved in competence and penicillin susceptibility in Staphylococcus epidermidis.J Basic Microbiol. 2016 ;56(4):358-68.

17.Liu D, Deng Q, Sun L, Wang T, Yang Z, Chen H, Guo L, Liu Y, Ma Y, Guo N, Shi M.A Her2-let-7-β2-AR circuit affects prognosis in patients with Her2-positive breast cancer.BMC Cancer. 2015;15:832.

18.Zhao Y, Wang Q, Qiu G, Zhou S, Jing Z, Wang J, Wang W, Cao J, Han K, Cheng Q, Shen B, Chen Y, Zhang WJ, Ma Y, Zhang J.RACK1 Promotes Autophagy by Enhancing the Atg14L-Beclin 1-Vps34-Vps15 Complex Formation upon Phosphorylation by AMPK.Cell Rep. 2015;13(7):1407-17.

19.Jiang Q, Zhang Z, Li S, Wang Z, Ma Y*, Hu Y.Defective heat shock factor 1 inhibits the growth of fibrosarcoma derived from simian virus 40/T antigen?transformed MEF cells.Mol Med Rep.2015;12(5):6517-26.

20.Jiang X, Yu J, Shi Q, Xiao Y, Wang W, Chen G, Zhao Z, Wang R, Xiao H, Hou C, Feng J,Ma Y, Shen B, Wang L, Li Y, Han G.Tim-3 promotes intestinal homeostasis in DSS colitis by inhibiting M1 polarization of macrophages.Clin Immunol.2015 Oct; 160(2):328-35.

21.Tan Q, Wang H, Hu Y, Hu M, Li X, Aodeng Q, Ma Y, Wei C, Song L.Src/STAT3-dependent HO-1 induction mediates chemoresistance of breast cancer cells to doxorubicin by promoting autophagy.Cancer Sci. 2015;106(8):1023-32.

22.Ma W, Zhang Y, Mu H, Qing X, Li S, Cui X, Lou Q, Ma Y, Pu H, Hu Y.Glucose regulates heat shock factor 1 transcription activity via mTOR pathway in HCC cell lines.Cell Biol Int. 2015 Nov;39(11):1217-24.

23.Jiang Q, Zhang Z, Li S, Wang Z, Ma Y*, Hu Y.Defective heat shock factor 1 inhibits the growth of fibrosarcoma derived from simian virus 40/T antigen?transformed MEF cells.Mol Med Rep.2015;12(5):6517-26..

24.Huang H, Song Y, Wu Y, Guo N, Ma Y*, Qian L.Erbin loss promotes cancer cell proliferation through feedback activation of Akt-Skp2-p27 signaling.BBRC.2015 Jul 31;463(3):370-6.

25.Zhao Y, Zhu T, Zhang X, Wang Q, Zhang J, Ji W, Ma Y.*.Splicing factor 2/alternative splicing factor contributes to extracellular-signal regulated kinase activation in hepatocellular carcinoma cells.Mol Med Rep. 2015;12(3):3890-4.

26.Wang WD, Wen Z, Ji W, Ma Y*.RACK1 expression contributes to JNK activity, but JNK activity does not enhance RACK1 expression in hepatocellular carcinoma SMMC-7721 cells.Oncol Lett. 2015;9(6):2767-70.

27.Yang Z, Guo L, Liu D, Sun L, Chen H, Deng Q, Liu Y, Yu M, Ma Y, Guo N, Shi M.Acquisition of resistance to trastuzumab in gastric cancer cells is associated with activation of IL-6/STAT3/Jagged-1/Notch positive feedback loop.Oncotarget. 2015;10;6(7):5072-5087.

28.Liu F,Si Y,Liu G,Li S,Zhang J,Ma Y*.The tetravalent anti-DR5 antibody without cross-linking direct induces apoptosis of cancer cells.Biomed Pharmacother. 2015;70:41-5.

29.Cui X, Xie PP, Jia PP, Lou Q, Dun G, Li S, Liu G, Zhang J, Dong Z, Ma Y, Hu Y.Hsf4 counteracts Hsf1 transcription activities and increases lens epithelial cell survival in vitro.Biochim Biophys Acta.2015;16;1853(3):746-755.

30.Qi YJ, Ward DG, Pang C, Wang QM, Wei W, Ma J, Zhang J, Lou Q, Shimwell NJ, Martin A, Wong N, Chao WX, Wang M, Ma YF*, Johnson PJ. Proteomic profiling of N-linked glycoproteins identifies ConA-binding procathepsin D as a novel serum biomarker for hepatocellular carcinoma. Proteomics. 2014 ;14(2-3):186-95.

31.Yi-Jun Qi, Ming Wang, Rui-Min Liu, Hua Wei, Wei-Xia Chao, Tian Zhang, Qiang Lou, Xiu-Min Li,Jin Ma, Han Zhu, Zhen-Hua Yang, Hai-Qing Liu, Yuan-Fang Ma*. Downregulation of 14-3-3s Correlates with Multistage Carcinogenesis and Poor Prognosis of Esophageal Squamous Cell Carcinoma.PLoS One. 2014;17;9(4):e95386

32.Wang W,Zhang Y,Lv M,Feng J,Peng H,Geng J,Lin Z,Zhou T,Li X,Shen B,Ma Y*,Qiao C.Anti-IGF-1R monoclonal antibody inhibits the carcinogenicity activity of acquired trastuzumab-resistant SKOV3.J Ovarian Res. 2014;7(1):103.

33.Zhao Z,Jiang X,Kang C,Xiao Y,Hou C,Yu J,Wang R,Xiao H,Zhou T,Wen Z,Feng J,Chen G,Ma Y*,Shen B,Li Y,Han G.Blockade of the T cell immunoglobulin and mucin domain protein 3 pathway exacerbates sepsis-induced immune deviation and immunosuppression.Clin Exp Immunol. 2014;178(2):279-91.

34.Qiang Lou, Wei Zhang, Guangchao Liu, Yuanfang Ma*.The C-Type Lectin OCILRP2 Costimulates EL4 T Cell Activation via the DAP12-Raf-MAP Kinase Pathway.PLoS One.2014;20;9(11):e113218.

35.Jiang Q,Zhang Z,Hu Y,Ma Y*.Function of Hsf1 in SV40 T‐antigen‐transformed HEK293T cells.Mol Med Report2014,10: 3139-3144.

36.Lihui Chai, Suxia Wu, Guangchao Liu, Zhanzheng Wang ,Wenzhi Tian,Yuanfang Ma*. OCILRP2 signaling synergizes with LPS to induce the maturation and differentiation of murine dendritic cells.BBRC,2014;18;446(4):836-42.

37.Qiang Lou,Yijun Qi,Yuanfang Ma*,Di Qu.Two-Component Signal Transduction System SaeRS Positively RegulatesStaphylococcus epidermidisGlucose Metabolism.ScientificWorldJournal. 2014 Jan 23.

38.Zhang J,Ma Z,Wang J,Li S,Zhang Y,Wang Y,Wang M,Feng X,Liu X,Liu G,Lou Q,Cui X,Ma Y,Dong Z,Huyz.Regulation of Hsf4b nuclear translocation and transcription activity by phosphorylation at threonine 472.Biochim Biophys Acta.2013,17;1843(3):580-589.

39.Shi M,Yang Z,Hu M,Liu D,Hu Y,Qian L,Zhang W,Chen H,Guo L, Yu M,Song L, Ma Y*,Guo N.Catecholamine-Induced β2-Adrenergic Receptor Activation Mediates Desensitization of Gastric Cancer Cells to Trastuzumab by Upregulating MUC4 Expression.J Immunol.2013 ;190(11):5600-8.

40.Yang X, Jiang X, Chen G, Xiao Y, Geng S, Kang C, Zhou T, Li Y, Guo X, Xiao H, Hou C, Wang R, Lin Z, Li X, Feng J, Ma Y*, Shen B, Li Y, Han G. T Cell Ig Mucin-3 Promotes Homeostasis of Sepsis by Negatively Regulating the TLR Response.J Immunol.2013; 190:2068-79.

41.Guo Y, Wang W, Wang J, Feng J, Wang Q, Jin J, Lv M, Li X, Li Y, Ma Y, Shen B, Zhang J. Receptor for activated C kinase 1 promotes hepatocellular carcinoma growth by enhancing mitogen-activated protein kinase kinase 7 activity. Hepatology.2013;57(1):140-51.

42.Hu YZ, Zahng J, Li S, Wang C, Chu L, Zhang Z, Ma Z, Wang M, Jiang Q, Liu G, Qi Y,Ma Y*.The transcription activity of heat shock factor 4b is regulated by FGF2.Int J Biochem Cell Biol.2013;45(2):317-25.

43.Zhao K, Wang Y, Wang X, Wang Y, Ma Y*.Tagged and untagged TRAIL show different activity against tumor cells. Oncol Lett. 2012;4(6):1301-1304.

44.Qiao C, Hu M, Guo L, Lv M, Lin Z, Geng J, Lang X, Li X, Li Y, Ma Y, Feng J, Shen B. Structural basis of LaDR5, a novel agonistic anti-death receptor 5 (DR5) monoclonal antibody, to inhibit DR5/TRAIL complex formation. BMC Immunol. 2012;13(1):40.

45.Sun H, Zhuang G, Chai L, Wang Z, Johnson D, Ma Y, Chen YH.TIPE2 Controls Innate Immunity to RNA by Targeting the Phosphatidylinositol 3-Kinase-Rac Pathway. J Immunol. 2012;189(6):2768-73.

46.Wei Y, Ma Y(co-first-auther), Zhao Q, Ren Z, Li Y, Hou T, Peng H.New Use for an Old Drug:Inhibiting ABCG2 with Sorafenib.Mol Cancer Ther.2012;11:1693-1702.

47.Xiaoke Gu, Zhiguang Ren, Xiaobo Tang,Hui Peng,Yuanfang Ma,Yisheng Lai,Sixun Peng,Yihua Zhang. Synthesis and biological evaluation of bifendate–chalcone hybrids as a new class of potential P-glycoprotein inhibitors. Bioorg Med Chem.2012;20(8):2540-8.

48.Xiaobo Tang, Xiaoke Gu, Zhiguang Ren,Yuanfang Ma,Yisheng Lai,Hui Peng,Sixun Peng,Yihua Zhang. Synthesis and evaluation of substituted dibenzo[c,e]azepine-5-ones as P-glycoprotein-mediated multidrug resistance reversal agents.Bioorg Med Chem Lett.2012; 22(8):2675-80.

49.Shi M, Zhao M, Hu M, Liu D, Cao H, Qian L, Yang Z, Hu Y, Yu M, Yang S, Ma Y*, Guo N.β2-AR-induced Her2 transactivation mediated by Erbin confers protection from apoptosis in cardiomyocytes. Int J Cardiol. 2013;167:1570-77.

50.Shi M,Du L,Liu D,Qian L,Hu M,Yu M,Yang Z,Zhao M,Chen C,Guo L,Wang L,Song L,Ma Y*,Guo N.Glucocorticoid regulation of a novel HPV E6-p53-miR-145 pathway modulates invasion and therapy resistance of cervical cancer cells.J Pathol.2012;228(2):148-57.

获得专利:

1.死亡受体5激动性多价抗体及其制备抗肿瘤药物中的应用,专利号:ZL201210457342.7.发明人:马远方,刘峰涛,张军,李淑莲,刘广超。

2.人sDR5蛋白或sDR5-Fc抗体融合蛋白作为心肌梗死治疗药物的应用,专利号:ZL 201210442685.6,发明人:马远方,王耀辉,王明丽,张军,刘广超,李淑莲,刘峰涛,胡延忠。申请国际PCT。

3.sDR5-Fc融合蛋白突变体及其应用。申请号:201510510981.9,发明人:马远方 王耀辉 张海龙 王明丽 张军 刘广超 李淑莲 顿国庆 胡延忠 祝伟娜。

获奖情况:

1.TRAIL-R2的表达与肿瘤诊断、治疗及预后相关性研究,2008-J-152-R01/01,河南省科技进步奖,二等,2008年11月,第一名。

2.抗死亡受体5单抗在恶性肿瘤诊断治疗中的应用,2007-J-147- R01/01,河南省科技进步奖,二等,2007年11月,第一名。

3.支原体试剂盒的研制及应用研究,2001-J-291-R01/07,河南省科技进步奖,三等,2002年5月,第一名。

讲授课程:免疫学


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